I went into this film without the context of knowing about Elizabeth Holmes or that Nathan Fielder was directing this, so I assumed for a out half the movie after I saw Nathan that this was a mockumentary. I think the fact that the things that were being said were consistently so insane that it did not break my notion that this was fake really frames how insane this whole project was, and it only got more insane and ridiculous.
I think one of the greatest compliments that you can pay is saying that you cannot remove someone from a work or event without removing the essence of that thing, and similarly I don't think anyone could have navigated this insanity, cringe, and unblinking lizard person stares (for godssake Billy has a room full of reptiles the jokes write themselves) and produced this level of narrative besides Nathan Fielder.